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Heparin and Dextrose ve Trombositopeni

Heparin and Dextrose ilacının Trombositopeni hastalığı ile etkileşiminin güvenlik kontrolünün sonucu.

Kontrolün sonucu:

Heparin and Dextrose <> Trombositopeni

Güncellik: 23.07.2019 Eleştirmen: MD PHD P.M. Shkutko, in

Drugs.com, Rxlist.com, Webmd.com, Medscape.com gibi yetkili kaynaklara dayalı kontrolün sonucunda bu ilacın bu komorbid hastalık ile etkileşmesi halinde zarar verebilen veya olumsuz etkisini artırabilen kontrendikasyonlar veya yan etkiler bulundu.

Tüketici:

Heparin kullanımı ciddi trombositopeni olan hastalarda kullanılmamalıdır. Akut trombositopeni heparin alan hastalarda %30'a kadar bildirilen bir risk olabilir. Trombosit sayısı önce ve periyodik olarak heparin sırasında elde edilen, 5 günden daha uzun bir süre için verilen heparin floş çözümleri düzenli ve tekrar kullanımı da dahil edilmelidir. 100.000/mm3 yukarıdaki sayıları ile hafif trombositopeni ters devam heparin rağmen kararlı kalabilecek. Ancak, herhangi bir derecede trombositopeni yakından takip edilmelidir. Eğer tedavi sayısı 100.000 altında gerekirse hastaların total/veya tekrarlayan tromboz gelişirse, alternatif, (örneğin, argatroban, bivalirudin, lepirudin) nonheparin antikoagülan uygulanan düşerse kesilmelidir. (HİT), Heparin kaynaklı trombositopeni trombosit ve geri toplama kaynaklanan ciddi bir antikor-aracılı reaksiyon. HİT venöz ve arteryel tromboz gelişimi için ilerleme olabilir, bir durum için heparin (HİTT)-trombositopeni ve tromboz olarak anılacaktır. Trombotik olaylar da HİTT ilk sunumu olabilir ve amputasyon yol açabilir, ve muhtemelen ölüm olabilir ekstremite derin ven trombozu, pulmoner emboli, serebral tromboz, ekstremite iskemisi, inme, miyokard infarktüsü, mezenterik tromboz, renal arter trombozu, cilt nekrozu, gangren olabilir. İkisi de vuruldu ve HİTT, heparin tedavisi kesildikten sonra ortaya birkaç hafta geçebilir. Trombositopeni ve tromboz ile heparin kesildikten sonra başvuran hastalarda VURDU ve HİTT için değerlendirilmelidir. Bir bölüm sonrasında, heparin gelecekteki her türlü kullanımını kaçınılmalıdır, ve düşük moleküler ağırlıklı heparin kullanımı HİT antikoru ile çapraz Reaktivite potansiyeli düşünün, aksi takdirde kullanılmamalıdır aşırı dikkatle ele alınmalıdır.

Kaynaklar

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